Proline dehydrogenase is a positive regulator of cell death in different kingdoms
نویسندگان
چکیده
منابع مشابه
Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.
Proline metabolism has an underlying role in apoptotic signaling that influences tumorigenesis. Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. Paradoxical to its role in apoptos...
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ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2011
ISSN: 1559-2324
DOI: 10.4161/psb.6.8.15791